Etrasimod | Veterans Affairs (2024)

Brand Name(s): Velsipity®

WHY is this medicine prescribed?

Etrasimod is used to treat moderate to severe active ulcerative colitis (a condition which causes swelling and sores in the lining of the colon [large intestine] and rectum) in adults. Etrasimod is in a class of medications called sphingosine l-phosphate receptor modulators. It works by decreasing the action of immune cells that may cause damage in the intestine.

HOW should this medicine be used?

Etrasimod comes as a tablet to take by mouth. It is usually taken with or without food once a day. Take etrasimod at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take etrasimod exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor will order a series of tests prior to putting you on etrasimod and may also recommend you receive certain vaccines. It is important to keep these testing and vaccination appointments to keep your treatment with etrasimod from being delayed.

Swallow the tablets whole; do not split, chew, or crush them.

Etrasimod controls ulcerative colitis but does not cure it. Continue to take etrasimod even if you feel well. Do not stop taking etrasimod without talking to your doctor.

Are there OTHER USES for this medicine?

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What SPECIAL PRECAUTIONS should I follow?

Before taking etrasimod,

  • tell your doctor and pharmacist if you are allergic to etrasimod, any other medications, or any of the ingredients in etrasimod oral tablets. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
  • some medications should not be taken with etrasimod. Other medications may cause dosing changes or extra monitoring when taken with etrasimod. Make sure you have discussed any medications you are currently taking or plan to take before starting etrasimod with your doctor and pharmacist. Before starting, stopping, or changing any medications while taking etrasimod, please get the advice of your doctor or pharmacist.
  • the following nonprescription or herbal products may interact with etrasimod: St. John's Wort. Be sure to let your doctor and pharmacist know that you are taking these medications before you start taking etrasimod. Do not start any of these medications while taking etrasimod without discussing with your healthcare provider.
  • tell your doctor if you have or have had angina (chest pain), heart disease, an arrhythmia (irregular heart beat) or heart failure or have had a heart attack or stroke. Your doctor may tell you not to take etrasimod.
  • tell your doctor if you have an active or chronic infection, including herpes or shingles, or have or have ever had a suppressed or weakened immune system (from either a condition or a medication), have chickenpox or have received the chickenpox vaccine, recently received or are scheduled to receive a vaccine, an abnormal or slow heart rate, liver disease, macular edema (swelling in the retina), high blood pressure, history of repeated fainting, skin cancer, or breathing problems (such as asthma, COPD, emphysema, or sleep apnea).
  • tell your doctor if you are pregnant or plan to become pregnant. Etrasimod may harm the unborn baby if taken during pregnancy. Your doctor may order a pregnancy test before you can start etrasimod. If you are a woman who can become pregnant, you should use effective birth control during and for 7 days following your final dose of etrasimod. Talk to your doctor or pharmacist about what birth control may be best for you. If you become pregnant while taking, or within 7 days of stopping, etrasimod, call your doctor immediately.
  • tell your doctor if you are planning to breastfeed while taking etrasimod.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking etrasimod.
  • plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Etrasimod may increase your risk of developing skin cancer.
  • do not have any vaccinations without talking to your doctor.
  • you should know that etrasimod has caused serious infections such as progressive multifocal leukoencephalopathy (PML) and cryptococcal infection (a fungal infection that can affect lungs or brain tissue). Call your doctor right away if you have any of the following symptoms: fever or high temperatures, tiredness, flu-like symptoms, or headache with fever, stiff neck, sensitivity to light, nausea, or confusion.
  • you should know that etrasimod has caused slow heart rate. Call your doctor right away if you have any of the following symptoms: feeling dizzy, feeling lightheaded, feeling your heart is beating slowly or skipping beats, shortness of breath, confusion, fatigue or tiredness, or chest pain.

What SPECIAL DIETARY instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I do IF I FORGET to take a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What SIDE EFFECTS can this medicine cause?

Etrasimod may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • headache
  • dizziness
    • nausea, vomiting, abdominal pain, tiredness, loss of appetite, yellowing of the skin or eyes, dark colored urine
    • blurriness or shadows in your vision, sensitivity to light, a blind spot in the center of your vision, unusually colored vision
    • changes in the appearance of your skin or new or changed moles or skin lesions
    • sudden severe headache, sudden confusion, loss of vision or changes in vision, seizure
    • shortness of breath
    • difficulty or pain on urination or increased frequency of urination
    • cough, difficulty breathing, severe congestion

Etrasimod may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online ( or by phone (1-800-332-1088).

What should I know about STORAGE and DISPOSAL of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach.

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website ( for more information if you do not have access to a take-back program.

What should I do in case of OVERDOSE?

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

What OTHER INFORMATION should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests to check your body's response to etrasimod.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.

The American Society of Health-System Pharmacists, Inc. represents that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. makes no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. does not endorse or recommend the use of any drug. The information is not a substitute for medical care.

AHFS® Patient Medication Information™. © Copyright, 2024. The American Society of Health-System Pharmacists®, 4500 East-West Highway, Suite 900, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.

Selected Revisions: November 15, 2023.

Etrasimod | Veterans Affairs (2024)


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What not to say at a C&P exam. The most vital thing not to do at your claim exam is to pretend your symptoms aren't as bad as they are. It's not the time to play tough. You don't want to exaggerate your symptoms, but you should be honest about how bad they are and exactly how they impact your life.

Can VSO see C&P exam results? ›

Option #1: The fastest way to get your C&P exam results is to have your accredited VSO download copies of the final exam report from the Veteran Benefits Management System (VBMS). This is a system that only accredited representatives have access to.

What is the 70-40 rule for VA disability? ›

To be eligible for schedular TDIU benefits, a veteran must have either: a single service-connected condition with a rating of at least 60 percent; or. (the 70/40 rule) at least two service-connected conditions with a combined rating of at least 70 percent, with at least one of the conditions rated 40 percent or higher.

Is the VA C&P exam no longer needed? ›

Does everyone who files a claim need to have a C&P exam? No. VA will ask you to have a claim exam only if we more information is needed to decide your claim. If you have enough medical evidence in your file to support your claim, VA won't ask you to have a claim exam.

What is the 5 year rule for VA disability? ›

The 5-year rule protects Veterans by not allowing the VA to assume that a service-connected condition has improved over time or that the Veteran has made a complete recovery. In some cases where this assumption was made, the Veteran had their benefits lowered or discontinued.

Is the VA disability going away in 2024? ›

Under that phaseout, veterans whose gross household income was $170,000 or higher in calendar year 2023 and who would have received the average annual payment would no longer receive any disability compensation from VA in calendar year 2024.

What claims can the VA not prove? ›

No, there aren't any VA disability claims that cannot be proven. In fact, all VA claims must be proven on an “at least as likely as not” basis. If you have no evidence (no proof), your VA claim will be denied. Also, you must first ensure you're even eligible for VA disability benefits under the law.

Can the VA give a rating without C&P exam? ›

Failing to attend a C&P exam that has been requested can be detrimental to a veteran's claim, and even lead to a denial. However, VA C&P exams are not required for every disability claim and are not guaranteed to be requested.

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During the C&P exam, you should make an effort to descriptively discuss your symptoms. Appreciating this may be difficult, it is crucial to provide specific examples of how your condition impacts daily life, relationships, work, and overall functioning, especially if it has an impact on your income-earning potential.

How do you fight a bad C&P exam? ›

Call the VA at 1-800-827-1000. Read them your MFR and tell them you are requesting another C&P exam. Upload your MFR to your claim. Leave a google review of the doctor to help other veterans.

How do you win a PTSD C&P exam? ›

Remember, this exam is the chance to show how Post-Traumatic Stress Disorder affects your life day-to-day. Details that a veteran might think are not important could be the key to their claim. The examiner needs to know all the details of the veteran's situation in order to make a decision about their claim.

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